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Table 2 Weight changes after 9 weeks of treatment in female Sprague–Dawley rats (cohort C) assessed in the study of the effect of exogenous estrogen and SERM in ovariectomy

From: Ovariectomized rats as a model of postmenopausal osteoarthritis: validation and application

  

Weight (g)

Treatment

n

Of body at start

Of body at end

Of uterus at end

OVX, vehiclea

12

269 ± 26

320 ± 31

0.13 ± 0.04

OVX, estrogen

11

273 ± 27

296 ± 26*

0.44 ± 0.14***

OVX, lowb SERM

11

269 ± 26

319 ± 33

0.18 ± 0.05**

OVX, highc SERM

12

268 ± 23

287 ± 24*

0.19 ± 0.03***

Sham operation, vehiclea

10

276 ± 26

303 ± 29

0.66 ± 0.10***

  1. Values are means ± SD. aVehicle (50% propylene glycol, 0.075 M NaCl); bLow dose (0.2 mg/kg per day); cHigh dose (5 mg/kg per day). Difference from the OVX group treated with vehicle only, assessed using the nonparametric Mann-Whitney U test: *P < 0.05, **P < 0.01, ***P < 0.001. OVX, ovariectomized; SERM, selective estrogen receptor modulator ((-)-cis-3,4-7-hydroxy-3-phenyl-4-(4-(2-pyrrolidinoethoxy)phenyl)chromane).
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Arthritis Research & Therapy

ISSN: 1478-6362

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