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Table 3 Correlations between histologically assessed cartilage erosion scores and markers of bone (CTX-I) and cartilage (CTX-II) turnover in the knees of female Sprague–Dawley rats

From: Ovariectomized rats as a model of postmenopausal osteoarthritis: validation and application

   

Changes in CTX-I

Changes in CTX-II

Cohorta (treatment)

 

Age at start (months)

From weeks 0–4

At week 4

From weeks 0–4

At week 4

A (OVX or shamb) (n = 18)

 

5

    

   Cartilage erosion:

Total

 

0.10

0.15

0.50

0.27

 

Medial femur

 

0.47

-0.02

0.64*

0.51*

B (OVX or shamb) (n = 17)

 

7

    

   Cartilage erosion:

Total

 

0.24

0.25

0.74**

0.54*

 

Medial femur

 

0.24

0.41

0.70**

0.63**

C (OVX + intervention or shamb) (n = 56)

 

5

    

   Cartilage erosion:

Total

 

0.40**

0.34*

0.50***

0.43**

 

Medial femur

 

0.35*

0.33*

0.37**

0.45**

  1. Values are Spearman's rho. aCohorts: A, see Table 1; B, see Table 1; C, intervention with either estrogen or SERM – see Table 2. bSham operation. *P < 0.05, **P < 0.01, ***P < 0.001. CTX-I, collagen type I fragments; CTX-II, collagen type II fragments.