Association of a specific haplotype across the genes MMP1 and MMP3 with radiographic joint destruction in rheumatoid arthritis

Table 4 Odds ratio (OR) and 95% confidence interval (CI) for the achievement of a Ratingen score above the median

	Sample 1				Sample 2
Parameter	OR	95% CI	P	n	OR	95% CI	P	n
No 1G/5A haplotypes vs two haplotypes	2.85	1.08–7.52	0.032	74	0.75	0.23–2.7	n.s.	37
MMP1 2G/2G vs MMP1 1G/1G	2.41	1.20–4.84	0.012	138	0.31	0.11–0.86	0.023	64
MMP3 5A/5A vs MMP3 6A/6A	1.69	0.86–3.32	n.s.	144	1.76	0.66–4.68	n.s.	69
SE-positive vs SE-negative	3.03	1.24–7.39	0.013	104	4.6	1.34–15.8	0.012	54

P values given are asymptotic P values. Sample 1: radiographs taken earlier than 15 years after disease onset. Sample 2: radiographs taken after more than 15 years of rheumatoid arthritis. MMP, matrix metalloproteinase; SE, shared epitope of HLA DR 4 and DR1.

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