Figure 1

Suppression of arthritis in mice that received oral type II collagen (CII) before arthritis induction. Mice that were given six consecutive administrations of 100 μg CII orally before induction of arthritis exhibited a marked reduction in arthritis index as compared with nontolerized collagen-induced arthritis (CIA) controls throughout the period of examination (i.e. from 2 to 11 weeks after the primary CII immunization for CIA induction.) The data represent average values from 15 individual mice in each group.