Figure 2
Serum levels of (a) IgG1 and (b) IgG2a subtypes in tolerized and nontolerized collagen-induced arthritis (CIA) mice. When examined at 3, 5 and 7 weeks after primary immunization, mice that received oral type II collagen (CII) exhibited higher serum levels of IgG1 than did nontolerized mice at all three time points, whereas the IgG2a level was lower in the tolerized group. The data represent average values from 15 mice in each group.
