Figure 3

T-cell proliferative response to antigenic stimulation with type II collagen (CII). T cells were isolated from draining lymph nodes and spleens of mice killed at 3, 5 and 7 weeks after primary immunization, and were cultured for 72 hours in the presence of 40 μg/ml CII. Panels show changes in the stimulation index (SI) of T cells isolated from (a) draining lymph node and (b) spleen. The data represent average values from 15 mice in each group.