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Table 1 Serum IL-6, serum amyloid A and corticosterone during zymosan-induced arthritis in ob/ob and +/? mice

From: Delayed resolution of acute inflammation during zymosan-induced arthritis in leptin-deficient mice

Time IL-6 (pg/ml) SAA (μg/ml) Corticosterone (ng/ml)
  +/? ob/ob +/? ob/ob +/? ob/ob
Baseline <39.0 <39.0 21.6 ± 2.6 25.3 ± 2.5 65.6 ± 15.0 140.6 ± 12.5a
6 hours 518.0 ± 52.8 1034.1 ± 114.8a 331.9 ± 14.8 191.8 ± 18.7b 164.5 ± 15.9 216.3 ± 15.8a
24 hours 85.7 ± 25.6 154.1 ± 59.2 456± 5 ± 23.4 810.6 ± 48.3c 56.9 ± 8.5 149.4 ± 31.9a
72 hours <39.0 <39.0 30.9 ± 4.6 387.5 ± 48.8c 70.3 ± 8.4 120.6 ± 19.3a
7 days ND ND 36.4 ± 2.2 184.8 ± 56.5a ND ND
14 days ND ND 131.8 ± 68.2 116.0 ± 30.1 ND ND
  1. Data shown represent means ± SEM of five to six mice per group. The results are representative of five independent experiments. Differences between groups were analyzed using one-way analysis of variance. aP < 0.05; bP < 0.0002; cP < 0.0001 for ob/ob versus +/? mice. ND, not done; SAA, serum amyloid A.