Figure 1From: Heterogeneous nuclear ribonucleoproteins C1/C2 identified as autoantigens by biochemical and mass spectrometric methodsIndirect immunofluorescence pattern of anti-C1/C2-positive patient serum on HEp-2 cells. Cells were incubated with diluted patient serum (1:160), and bound IgG was detected by fluorescence microscopy after incubation with fluoresceinylated rabbit anti-human IgG. Strongly positive, very regular, coarse nuclear staining that spares nucleoli is observed. Original magnification is 200×. Scale bar is 10 μm.Back to article page