Table 1 Gene expression studies of peripheral blood mononuclear cells from patients with autoimmune diseases

Subjects studied

Gene arrays used

Summary

Reference

MS (n = 27) and normal controls (n = 19)

14,000 cDNA clones

MS patients distinguished from normal controls using 53 discriminatory genes

Bomprezzi et al., 2003 [12]

MS (n = 10)

Mini-lymphochip with >12,000 elements

Identification of a set of genes regulated by IFN-ß

Sturzebecher et al., 2003 [13]

SLE (n = 21) and normal controls (n = 12)

Cytokine gene array with 375 genes in duplicate

Clustering distinguished most patients from controls

Rus et al., 2002 [14]

SLE (n = 48) and normal controls (n = 42)

Affymetrix U95A array with >10,000 genes

Dysregulation of genes in the IFN pathway present in SLE patients with active disease

Baechler et al., 2003 [15]

Pediatric SLE (n = 30); JCA (n = 12); normal children (n = 9)

Affymetrix U95AV2 array with >12,000 genes

SLE patients had overexpression of granulopoiesis-related and IFN-induced genes related to the presence of active disease

Bennett et al., 2003 [16]

SLE, RA, MS, IDDM (n = 53) and normal controls (n = 9)

Research Genetics/Invitrogen with >4300 genes

Autoimmune patients clustered separately from normal and immunized controls

Maas et al., 2002 [17]