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Table 2 Cytokine production and proliferation of CD25- CD4+ T cells in in vitro cultures

From: CD25brightCD4+regulatory T cells are enriched in inflamed joints of patients with chronic rheumatic disease

Patient IFN-╬│(pg/ml) IL-10 (pg/ml) IL-13 (pg/ml) TNF (pg/ml) Proliferation (c.p.m.)
PsA 1a 6656 459 952 na 67,331
PsA 2b 4775 67 na 468 42,662
SpA 1a 879 bdl bdl na 13,086
SpA 2b 3681 bdl na 806 42,469
JIA 1b 1924 53 na 355 105,210
JIA 2b 1656 30 na 530 12,621
RA 1a 5677 385 293 na 106,269
RA 2b 608 bdl na 109 103,724
  1. Production of cytokines and proliferation of responder cells in patients with psoriatic arthritis (PsA), spondyloarthopathies (SpA), juvenile idiopathic arthritis (JIA) and rheumatoid arthritis (RA) are shown. Changes in cytokine and proliferation levels after coculture with CD25brightCD4+ T cells are shown in Fig. 5. bdl, below detection limit; IFN, interferon; IL, interleukin; na, not analyzed; TNF, tumor necrosis factor. aEnzyme-linked immunosorbent assay; detection limit is 50 pg/ml; 20,000 cells per well in coculture. bCytometric bead array; detection limit is 3 pg/ml; 5000 cells per well in coculture.