Altered expression of inflammatory cytokines in primary osteoarthritis by human T lymphotropic virus type I retrovirus infection: a cross-sectional study

Table 2 C-terminal parathyroid hormone (C-PTHrP) concentration, radiographic changes, histopathological features and Tax expression in synovia of human T lymphotropic virus type Icarriers with knee-joint osteoarthritis

Case	IgM	C-PTHrP (pM)	Operation	Kellgren/Lawrence scale^a		Interval (years)	Synovial proliferation	Inflammatory reaction	Tax expression^b
				Initial	Before operation
1	+	201	OST	IV	IV	3.4	+/-	-	+/-
2	-	154	TA	IV	IV	2.8	+	-	+
3	-	214	TA	IV	IV	1.2	+	+/-	+
4	+	439	TA	IV	IV	3.5	+	+/-	++
5	-	567	OST	III	IV	2.1	+	+/-	+
6	+	813	SYV	II	III	1.5	++	+	++
7	+	955	SYV	III	III	0.3	++	+	+
8	-	644	TA	IV	IV	0.5	+	+/-	+

The degrees of synovial proliferation and inflammatory reaction were semi-quantified as described in Materials and methods. ^aScoring was as follows: II, minimal osteophytes possibly with narrowing, cyst and sclerosis; III, moderate or definite osteophytes with moderate joint space narrowing; IV, severe with large osteophytes and definite joint space narrowing. ^bScoring was as follows: +/-, minimum staining in one area of the tissue; +, patchy staining involving several areas; ++, moderate diffuse staining. OST, osteotomy; SYV, synovectomy; TA, total joint arthroplasty.

ISSN: 1478-6362