Figure 6

Effect of diosgenin on prostaglandin E₂ (PGE₂) production by human rheumatoid arthritis fibroblast-like synoviocytes (FLS). Cells were cultured in 10% FCS medium for 48 hours and then treated or not with 40 μM diosgenin for 24 or 48 hours. The PGE₂ levels in the culture medium were measured by enzyme immunoassay. Measurements were made on FLS from four different patients. Data are expressed as mean ± SD of four experiments. *^,# A P-value of less than 0.05 (Fisher's protected-least-significant-difference test) was considered to indicate significance in comparison with the relevant controls.