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Table 1 Comparative effects of 1 α,25-dihydroxyvitamin D3 (1 α,25D3) on interleukin (IL)-1-stimulated matrix metalloproteinase (MMP)-1 and MMP-3 production by rheumatoid synovial fibroblasts and human articular chondrocytes in vivo

From: The effects of 1α,25-dihydroxyvitamin D3 on matrix metalloproteinase and prostaglandin E2 production by cells of the rheumatoid lesion

  Fibroblasts Chondrocytes
  MMP-1 MMP-3 MMP-1 MMP-3
Control 1 1 1 1
+ 1α,25D3   1.03 ± 0.27   2.07 ± 0.35 1.38 ± 0.19   1.59 ± 0.22
+ IL-1 31.09 ± 4.97 31.28 ± 8.49 3.45 ± 0.49   9.05 ± 0.62
+ IL-1 + 1α,25D3 15.55 ± 5.86 11.84 ± 2.82 3.71 ± 0.53 11.11 ± 0.31
  1. Data given are normalized relative to control values and are expressed ± SEM for three cultures of each cell type.
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