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Table 1 Comparative effects of 1 α,25-dihydroxyvitamin D3 (1 α,25D3) on interleukin (IL)-1-stimulated matrix metalloproteinase (MMP)-1 and MMP-3 production by rheumatoid synovial fibroblasts and human articular chondrocytes in vivo

From: The effects of 1α,25-dihydroxyvitamin D3 on matrix metalloproteinase and prostaglandin E2 production by cells of the rheumatoid lesion

 

Fibroblasts

Chondrocytes

 

MMP-1

MMP-3

MMP-1

MMP-3

Control

1

1

1

1

+ 1α,25D3

  1.03 ± 0.27

  2.07 ± 0.35

1.38 ± 0.19

  1.59 ± 0.22

+ IL-1

31.09 ± 4.97

31.28 ± 8.49

3.45 ± 0.49

  9.05 ± 0.62

+ IL-1 + 1α,25D3

15.55 ± 5.86

11.84 ± 2.82

3.71 ± 0.53

11.11 ± 0.31

  1. Data given are normalized relative to control values and are expressed ± SEM for three cultures of each cell type.
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Arthritis Research & Therapy

ISSN: 1478-6362

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