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Figure 3 | Arthritis Res Ther

Figure 3

From: Strong inhibition of TNF-α production and inhibition of IL-8 and COX-2 mRNA expression in monocyte-derived macrophages by RWJ 67657, a p38 mitogen-activated protein kinase (MAPK) inhibitor

Figure 3

Protein production of tumor necrosis factor (TNF)-α, IL-6, IL-8, and matrix metalloproteinase 9 (MMP9) by monocyte-derived macrophages from healthy controls (n = 8, open squares) and rheumatoid arthritis patients (n = 9, filled squares). Cells were stimulated with LPS for 24 hours and pretreated 1 hour beforehand with RWJ 67657 at various concentrations. Protein production was measured in supernatants by ELISA and is expressed in ng/ml (a). Inhibition was calculated against the stimulated control (b). Bars show mean and SEM. *P < 0.05; **P < 0.001, paired t-test, calculated versus the stimulated control. unst, unstimulated.

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