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Figure 4 | Arthritis Res Ther

Figure 4

From: Strong inhibition of TNF-α production and inhibition of IL-8 and COX-2 mRNA expression in monocyte-derived macrophages by RWJ 67657, a p38 mitogen-activated protein kinase (MAPK) inhibitor

Figure 4

Time course of induction of mRNA expression of tumor necrosis factor (TNF)-α, IL-1β, IL-6, IL-8, and cyclooxygenase 2 (COX-2). Monocyte-derived macrophages from healthy controls (n = 2) were stimulated for increasing periods of time with lipopolysaccharide (50 ng/ml). mRNA expression was determined with real-time RT-PCR and results were calculated as fold induction in comparison with unstimulated cells (fold induction = 1).

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