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Figure 5 | Arthritis Res Ther

Figure 5

From: Strong inhibition of TNF-α production and inhibition of IL-8 and COX-2 mRNA expression in monocyte-derived macrophages by RWJ 67657, a p38 mitogen-activated protein kinase (MAPK) inhibitor

Figure 5

mRNA expression of tumor necrosis factor (TNF)-α, IL-1β, cyclooxygenase 2 (COX-2), IL-6, IL-8, and matrix metalloproteinase 9 (MMP9) in monocyte-derived macrophages from healthy controls (n = 5). Cells were stimulated with lipopolysaccharide for 4 hours and pretreated with a RWJ 67657 at various concentrations. mRNA expression was determined with real-time RT-PCR and results are expressed as fold induction in comparison with unstimulated cells (fold induction = 1). Bars show means and SEM (*P < 0.05, paired t-test, calculated against the stimulated control).

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