A proinflammatory role for Fas in joints of mice with collagen-induced arthritis

Table 1 DBA-lpr/lpr mice are protected against collagen-induced arthritis

	No. of mice^a	Incidence (%)^b	Mean score^c at day 64	Mean day of onset^d
DBA/1J-lpr/lpr	34	44* ^e	1.6 ± 0.75*^f	51 ± 14
DBA/1J-lpr/+	33	81	5 ± 1.1	41 ± 6

DBA/1J-lpr/lpr and DBA/1J-lpr/+ mice were scored for arthritic lesions as described in Materials and methods. A summary of disease course in DBA/1J-lpr/lpr and their control littermates DBA/1J-lpr/+ is shown. ^a18 of the lpr/lpr mice and 16 of the lpr/+ mice are from Ma and co-workers [45]. ^bNumber of diseased mice divided by all mice. ^cScore of diseased mice divided by all mice ± SEM. ^dTotal of days of onset divided by the number of diseased mice ± SD. * ^eP < 0.05, χ² test. * ^fP < 0.05, Mann–Whitney U test.

ISSN: 1478-6362