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Table 3 Genotype distribution and allele frequency of estrogen receptor-α gene polymorphisms in patients with osteoarthritis and control individuals

From: Estrogen receptor-α gene haplotype is associated with primary knee osteoarthritis in Korean population

Groups ER-α genotypes ER-α alleles
   OA (%) Control (%) P a   OA (%) Control (%) P b OR (95% CI)
PvuII (T/C) TT 61 (40.4) 152 (38.3) 0.89 T 190 (62.9) 487 (61.3) 0.63 0.93 (0.71–1.23)
  CT 68 (45.0) 183 (46.1)       
  CC 22 (14.6) 62 (15.6)   C 112 (37.1) 307 (38.7)   
XbaI (A/G) AA 98 (64.9) 256 (64.5) 0.81 A 245 (81.1) 638 (80.3) 0.77 0.95 (0.68–1.33)
  AG 49 (32.4) 126 (31.7)       
  GG 4 (2.70) 15 (3.80)   G 57 (18.9) 156 (19.7)   
BtgI (G/A) GG 84 (55.6) 257 (64.7) 0.13 G 225 (74.5) 636 (80.1) 0.044 1.38 (1.01–1.88)
  GA 57 (37.8) 122 (30.7)       
  AA 10 (6.60) 18 (4.60)   A 77 (25.5) 158 (19.9)   
  1. A total of 151 patients with osteoarthritis (OA) and 397 control individuals were included in the study. aControl individuals versus patients using the χ2 test with 3 × 2 contingency table. bControl individuals versus patients using the χ2 test with 2 × 2 contingency table. CI, confidence interval; ER, estrogen receptor; OR, odds ratio.