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Table 3 Genotype distribution and allele frequency of estrogen receptor-α gene polymorphisms in patients with osteoarthritis and control individuals

From: Estrogen receptor-α gene haplotype is associated with primary knee osteoarthritis in Korean population

Groups

ER-α genotypes

ER-α alleles

  

OA (%)

Control (%)

P a

 

OA (%)

Control (%)

P b

OR (95% CI)

PvuII (T/C)

TT

61 (40.4)

152 (38.3)

0.89

T

190 (62.9)

487 (61.3)

0.63

0.93 (0.71–1.23)

 

CT

68 (45.0)

183 (46.1)

      
 

CC

22 (14.6)

62 (15.6)

 

C

112 (37.1)

307 (38.7)

  

XbaI (A/G)

AA

98 (64.9)

256 (64.5)

0.81

A

245 (81.1)

638 (80.3)

0.77

0.95 (0.68–1.33)

 

AG

49 (32.4)

126 (31.7)

      
 

GG

4 (2.70)

15 (3.80)

 

G

57 (18.9)

156 (19.7)

  

BtgI (G/A)

GG

84 (55.6)

257 (64.7)

0.13

G

225 (74.5)

636 (80.1)

0.044

1.38 (1.01–1.88)

 

GA

57 (37.8)

122 (30.7)

      
 

AA

10 (6.60)

18 (4.60)

 

A

77 (25.5)

158 (19.9)

  
  1. A total of 151 patients with osteoarthritis (OA) and 397 control individuals were included in the study. aControl individuals versus patients using the χ2 test with 3 × 2 contingency table. bControl individuals versus patients using the χ2 test with 2 × 2 contingency table. CI, confidence interval; ER, estrogen receptor; OR, odds ratio.