|
Groups
|
ER-α genotypes
|
ER-α alleles
|
|---|
| | |
OA (%)
|
Control (%)
|
P
a
| |
OA (%)
|
Control (%)
|
P
b
|
OR (95% CI)
|
|---|
|
PvuII (T/C)
|
TT
|
61 (40.4)
|
152 (38.3)
|
0.89
|
T
|
190 (62.9)
|
487 (61.3)
|
0.63
|
0.93 (0.71–1.23)
|
| |
CT
|
68 (45.0)
|
183 (46.1)
| | | | | | |
| |
CC
|
22 (14.6)
|
62 (15.6)
| |
C
|
112 (37.1)
|
307 (38.7)
| | |
|
XbaI (A/G)
|
AA
|
98 (64.9)
|
256 (64.5)
|
0.81
|
A
|
245 (81.1)
|
638 (80.3)
|
0.77
|
0.95 (0.68–1.33)
|
| |
AG
|
49 (32.4)
|
126 (31.7)
| | | | | | |
| |
GG
|
4 (2.70)
|
15 (3.80)
| |
G
|
57 (18.9)
|
156 (19.7)
| | |
|
BtgI (G/A)
|
GG
|
84 (55.6)
|
257 (64.7)
|
0.13
|
G
|
225 (74.5)
|
636 (80.1)
|
0.044
|
1.38 (1.01–1.88)
|
| |
GA
|
57 (37.8)
|
122 (30.7)
| | | | | | |
| |
AA
|
10 (6.60)
|
18 (4.60)
| |
A
|
77 (25.5)
|
158 (19.9)
| | |
- A total of 151 patients with osteoarthritis (OA) and 397 control individuals were included in the study. aControl individuals versus patients using the χ2 test with 3 × 2 contingency table. bControl individuals versus patients using the χ2 test with 2 × 2 contingency table. CI, confidence interval; ER, estrogen receptor; OR, odds ratio.
