Clinical subtypes | Genotype distributionsa | Allele frequenciesb | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
PvuII | XbaI | BtgI | PvuII | XbaI | BtgI | ||||||||||
TT | TC | CC | AA | AG | GG | GG | GA | AA | T | C | A | G | G | A | |
Women (n = 98) | 43 (43.9) | 42 (42.8) | 13 (13.3) | 64 (65.3) | 33 (33.7) | 1 (1.00) | 57 (58.2) | 35 (35.7) | 6 (6.10) | 128 (65.3) | 68 (34.7) | 161 (82.1) | 35 (17.9) | 149 (76.0) | 47 (24.0) |
χ2 = 3.84; P = 0.15 | χ2 = 1.05; P = 0.59 | χ2 = 0.23; P = 0.89 | 1.15 (0.80–1.64); P = 0.45 | 0.91 (0.58–1.41); P = 0.67 | 1.10 (0.74–1.65); P = 0.63 | ||||||||||
Men (n = 53) | 18 (34.0) | 26 (49.0) | 9 (17.0) | 34 (64.1) | 16 (30.2) | 3 (5.70) | 27 (75.5) | 22 (20.7) | 4 (3.80) | 62 (58.5) | 44 (41.5) | 84 (79.2) | 22 (20.8) | 76 (71.78) | 30 (28.3) |
χ2 = 1.69; P = 0.43 | χ2 = 0.07; P = 0.96 | χ2 = 6.28; P = 0.043 | 0.82 (0.53–1.27); P = 0.38 | 1.04 (0.62–1.78); P = 0.86 | 1.89 (1.15–3.11); P = 0.011 | ||||||||||
Early onsetc (n = 85) | 34 (40.0) | 41 (48.2) | 10 (11.8) | 52 (61.2) | 31 (36.5) | 2 (2.30) | 51 (60.0) | 29 (34.1) | 5 (5.90) | 109 (64.1) | 61 (35.9) | 135 (79.4) | 35 (20.6) | 131 (77.1) | 39 (22.9) |
χ2 = 0.82; P = 0.66 | χ2 = 1.00; P = 0.60 | χ2 = 0.77; P = 0.68 | 0.893 (0.63–1.25); P = 0.50 | 1.06 (0.70–1.60); P = 0.78 | 1.20 (0.80–1.78); P = 0.37 | ||||||||||
Late onsetc (n = 66) | 27 (40.9) | 27 (40.9) | 12 (18.2) | 46 (69.7) | 18 (27.3) | 2 (3.00) | 33 (50.0) | 28 (42.4) | 5 (7.60) | 81 (61.4) | 51 (38.6) | 110 (83.3) | 22 (16.7) | 94 (71.2) | 38 (28.8) |
χ2 = 0.67; P = 0.71 | χ2 = 0.68; P = 0.71 | χ2 = 5.40; P = 0.07 | 1.00 (0.68–1.46); P = 0.99 | 1.82 (0.50–1.33); P = 0.42 | 1.63 (1.07–2.46); P = 0.021 | ||||||||||
Mildd(n = 90) | 44 (48.9) | 33 (36.7) | 13 (14.4) | 67 (74.5) | 21 (23.3) | 2 (2.20) | 50 (55.6) | 33 (36.76) | 7 (7.80) | 121 (67.2) | 59 (32.8) | 155 (86.1) | 25 (13.9) | 133 (73.9) | 47 (26.1) |
χ2 = 3.58; P = 0.17 | χ2 = 3.32; P = 0.19 | χ2 = 0.30; P = 0.19 | 0.77 (0.55–1.09); P = 0.14 | 0.66 (0.42–1.04); P = 0.07 | 1.42 (0.98–2.07); P = 0.06 | ||||||||||
Severed (n = 61) | 17 (27.9) | 35 (57.4) | 9 (14.7) | 31 (50.8) | 28 (45.9) | 2 (3.30) | 34 (55.7) | 24 (39.3) | 3 (4.90) | 69 (56.6) | 53 (43.4) | 90 (73.8) | 32 (26.2) | 92 (75.4) | 30 (24.6) |
χ2 = 2.99; P = 0.22 | χ2 = 4.76; P = 0.09 | χ2 = 1.92; P = 0.38 | 1.22 (0.83–1.79); P = 0.31 | 1.45 (0.94–2.26); P = 0.09 | 1.31 (0.84–2.05); P = 0.23 | ||||||||||
Good indexe (n = 82) | 32 (39.0) | 35 (42.7) | 15 (18.3) | 52 (63.4) | 28 (34.2) | 2 (2.40) | 45 (54.9) | 31 (37.8) | 6 (7.30) | 99 (60.4) | 65 (39.6) | 132 (80.5) | 32 (19.5) | 121 (73.8) | 43 (26.2) |
χ2 = 0.68; P = 0.78 | χ2 = 0.48; P = 0.78 | χ2 = 3.16; P = 0.21 | 1.04 (0.74–1.47); P = 0.82 | 0.99 (0.65–1.51); P = 0.97 | 1.43 (0.97–2.11); P = 0.07 | ||||||||||
Poor indexe (n = 69) | 29 (42.0) | 33 (47.8) | 7 (10.2) | 46 (66.7) | 21 (30.4) | 2 (2.90) | 39 (56.5) | 26 (37.7) | 4 (5.80) | 91 (65.9) | 47 (34.1) | 113 (81.9) | 25 (18.1) | 104 (75.4) | 34 (24.6) |
χ2 = 1.44; P = 0.49 | χ2 = 0.20; P = 0.90 | χ2 = 1.72; P = 0.42 | 0.82 (0.56–1.20); P = 0.30 | 0.90 (0.57–1.44); P = 0.67 | 1.32 (0.86–2.01); P = 0.20 |