Estrogen receptor-α gene haplotype is associated with primary knee osteoarthritis in Korean population

Table 6 Comparison of estrogen receptor-α gene haplotypes in subtypes of osteoarthritis patients and control individuals

Haplotypes	Control	Early onset^a	Late onset^a	Mild^b	Severe^b	Good^c	Poor^c
TAG	0.41	0.41	0.41	0.43	0.39	0.39	0.44
TAA	0.09	0.16	0.18	0.18	0.15	0.16	0.17
TGG	0.09	0.07	0.02	0.06	0.02	0.05	0.05
TGA	0.03	<0.01	<0.01	<0.01	<0.01	<0.01	<0.01
CAG	0.25	0.19	0.17	0.19	0.16	0.19	0.17
CAA	0.06	0.04	0.07	0.06	0.04	0.06	0.04
CGG	0.06	0.10	0.11	0.05	0.18	0.11	0.10
CGA	0.02	0.04	0.04	0.02	0.06	0.04	0.03
		df = 7, χ² = 7.42; P^d = 0.390	df = 7, χ² = 21.96; P^d = 0.002	df = 7, χ² = 13.60; P^d = 0.059	df = 7, χ² = 23.96; P^d = 0.001	df = 7, χ² = 10.96; P^d = 0.14	df = 7, χ² = 14.66; P^d = 0.041

Values given are haplotype frequencies. ^aThe mean age at onset in the osteoarthritis (OA) patients was 52.0 years, and so early onset OA patients were defined as those with disease onset at age under 52 years, whereas late onset OA patients were those with onset at age over 52 years. ^bBased on radiographic findings, OA patients were classified as mild (Kellgren-Lawrence grade 1 or 2) or severe (Kellgren-Lawrence grade 3 or 4). ^cBased on Lequesne's functional index score, poor OA patients were defined as those with an index score over 10, whereas good OA patients were those with an index score less than or equal to 10. ^dP values for overall difference in haplotype distribution between OA patients and control individuals were calculated using the EH program [23]. df, degrees of freedom.

ISSN: 1478-6362