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Table 1 The impact of hormone replacement therapy (HRT) on biochemical markers of bone and cartilage metabolism

From: Hormone replacement therapy, calcium and vitamin D3 versus calcium and vitamin D3alone decreases markers of cartilage and bone metabolism in rheumatoid arthritis: a randomized controlled trial [ISRCTN46523456]

   At study entry At 12 months At 24 months
CTX-I (ng/ml) HRT 0.59 ± 0.37 (35) 0.21 ± 0.15 (32) †††,‡‡‡ 0.25 ± 0.16 (33) †††,‡‡‡
  Controls 0.63 ± 0.34 (46) 0.53 ± 0.41 (46) 0.66 ± 0.66 (42)
ICTP (μg/l) HRT 5.1 ± 2.1 (35) 4.7 ± 2.2 (29) ††, 4.9 ± 2.4 (33) †††,
  Controls 4.6 ± 1.7 (44) 5.8 ± 3.4 (46) 6.5 ± 5.4 (44) ‡‡
BSP (ng/ml) HRT 119.3 ± 39.6 (41) 126.8 ± 34.1 (33) 127.6 ± 47.8 (34)
  Controls 126.7 ± 35.7 (47) 139.5 ± 46.5 (47) 143.1 ± 45.3 (45)
PICP (μg/l) HRT 132.8 ± 40.0 (34) 104.0 ± 26.9 (29) ††,‡‡‡ 121.0 ± 31.9 (34)
  Controls 133.1 ± 42.7 (44) 132.6 ± 50.2 (46) 133.2 ± 40.0 (44)
COMP (U/l) HRT 11.0 ± 2.6 (39) 10.1 ± 2.9 (33) , 9.8 ± 2.7 (34) ††,‡‡
  Controls 11.3 ± 3.2 (47) 11.6 ± 2.8 (47) 11.8 ± 2.7 (45)
CTX-II (ng/mmol) HRT 1.1 ± 1.3 (41) 0.8 ± 0.8 (36) 0.9 ± 1.1 (34)
  Controls 1.2 ± 1.4 (44) 1.3 ± 1.5 (46) 1.1 ± 0.9 (44)
Estradiol (pmol/l) HRT 47.7 ± 47.9 (31) 177.6 ± 139.4 (25) †††,‡‡‡ 176.1 ± 124.0 (31) †††,‡‡‡
  Controls 37.2 ± 25.5 (40) 38.3 ± 33.2 (41) 37.8 ± 39.2 (38)
ESR (mm) HRT 30.8 ± 19.1 (41) 29.0 ± 18.8 (35) 24.3 ± 13.1 (35) ,‡‡
  Controls 26.5 ± 15.1 (46) 27.4 ± 19.8 (45) 26.3 ± 17.5 (44)
DAS 28 HRT 5.2 ± 1.0 (41) 4.4 ± 1.1 (35) ‡‡‡ 3.9 ± 1.0 (35) ,‡‡‡
  Controls 5.3 ± 1.0 (46) 4.8 ± 1.3 (45) ‡‡ 4.5 ± 1.1 (44) ‡‡‡
  1. Values are means ± SD. Numbers of patients with available data are shown in parentheses. P <0.05 for the comparison with controls from baseline with respects to differences; ††P < 0.01 for the comparison with controls from baseline with respects to differences; †††P < 0.001 for the comparison with controls from baseline with respects to differences; P < 0.05 for the comparison with baseline with respects to differences; ‡‡P < 0.01 for the comparison with baseline with respects to differences; ‡‡‡P < 0.001 for the comparison with baseline with respects to differences. BSP, bone sialoprotein; COMP, cartilage oligomeric matrix protein; CTX-I, type I collagen C-telopeptide fragments; CTX-II, type II collagen C-telopeptide; DAS, Disease Activity Score 28 [28]; ESR, erythrocyte sedimentation rate; ICTP, C-terminal telopeptide of type I collagen, PICP, C-terminal propeptide of type I procollagen.