Table 1 The impact of hormone replacement therapy (HRT) on biochemical markers of bone and cartilage metabolism

CTX-I (ng/ml)

HRT

0.59 ± 0.37 (35)

0.21 ± 0.15 (32) ^†††,^‡‡‡

0.25 ± 0.16 (33) ^†††,^‡‡‡

Controls

0.63 ± 0.34 (46)

0.53 ± 0.41 (46) ^‡

0.66 ± 0.66 (42)

ICTP (μg/l)

HRT

5.1 ± 2.1 (35)

4.7 ± 2.2 (29) ^††,^‡

4.9 ± 2.4 (33) ^†††,^‡

Controls

4.6 ± 1.7 (44)

5.8 ± 3.4 (46) ^‡

6.5 ± 5.4 (44) ^‡‡

BSP (ng/ml)

HRT

119.3 ± 39.6 (41)

126.8 ± 34.1 (33)

127.6 ± 47.8 (34)

Controls

126.7 ± 35.7 (47)

139.5 ± 46.5 (47) ^‡

143.1 ± 45.3 (45) ^‡

PICP (μg/l)

HRT

132.8 ± 40.0 (34)

104.0 ± 26.9 (29) ^††,^‡‡‡

121.0 ± 31.9 (34) ^‡

Controls

133.1 ± 42.7 (44)

132.6 ± 50.2 (46)

133.2 ± 40.0 (44)

COMP (U/l)

HRT

11.0 ± 2.6 (39)

10.1 ± 2.9 (33) ^†,^‡

9.8 ± 2.7 (34) ^††,^‡‡

Controls

11.3 ± 3.2 (47)

11.6 ± 2.8 (47)

11.8 ± 2.7 (45)

CTX-II (ng/mmol)

HRT

1.1 ± 1.3 (41)

0.8 ± 0.8 (36)

0.9 ± 1.1 (34) ^‡

Controls

1.2 ± 1.4 (44)

1.3 ± 1.5 (46)

1.1 ± 0.9 (44)

Estradiol (pmol/l)

HRT

47.7 ± 47.9 (31)

177.6 ± 139.4 (25) ^†††,^‡‡‡

176.1 ± 124.0 (31) ^†††,^‡‡‡

Controls

37.2 ± 25.5 (40)

38.3 ± 33.2 (41)

37.8 ± 39.2 (38)

ESR (mm)

HRT

30.8 ± 19.1 (41)

29.0 ± 18.8 (35)

24.3 ± 13.1 (35) ^†,^‡‡

Controls

26.5 ± 15.1 (46)

27.4 ± 19.8 (45)

26.3 ± 17.5 (44)

DAS 28

HRT

5.2 ± 1.0 (41)

4.4 ± 1.1 (35) ^‡‡‡

3.9 ± 1.0 (35) ^†,^‡‡‡

Controls

5.3 ± 1.0 (46)

4.8 ± 1.3 (45) ^‡‡

4.5 ± 1.1 (44) ^‡‡‡