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Table 3 Baseline correlations between biochemical markers of bone and cartilage metabolism, bone mineral density, and radiographic joint destruction

From: Hormone replacement therapy, calcium and vitamin D3 versus calcium and vitamin D3alone decreases markers of cartilage and bone metabolism in rheumatoid arthritis: a randomized controlled trial [ISRCTN46523456]

Biochemical marker ESR CTX-I ICTP BSP PICP CTX-II COMP BMD, forearm BMD, total hip BMD, lumbar spine Larsen score
ESR - 0.111 0.280* 0.088 0.026 0.257* 0.095 -0.171 -0.195 -0.100 0.500***
CTX-I 0.111 - 0.366** 0.194 0.401*** 0.129 0.099 -0.293* -0.253* -0.187 0.182
ICTP 0.280* 0.366** - -0.120 0.138 0.472*** 0.201 -0.255* -0.322** -0.129 0.449***
BSP 0.088 0.194 -0.120 - 0.195 0.047 -0.072 0.100 0.012 0.076 -0.045
PICP 0.026 0.401*** 0.138 0.195 - 0.069 0.264* -0.281* -0.205 -0.218 0.103
CTX-II 0.257* 0.129 0.472*** 0.047 0.069 - 0.160 -0.075 -0.170 0.073 0.361**
COMP 0.095 0.099 0.201 -0.072 0.264* 0.160 - 0.099 0.187 0.281** 0.271*
Estradiol 0.015 -0.077 0.020 0.020 -0.041 0.120 0.171 0.209 0.185 0.255* 0.008
  1. Radiographic joint destruction was assessed using the Larsen score [27]. *P < 0.05; **P < 0.01; ***P < 0.001. BMD, bone mineral density; BSP, bone sialoprotein; COMP, cartilage oligomeric matrix protein; CTX-I, type I collagen C-telopeptide fragments; CTX-II, type II collagen C-telopeptide; ESR, erythrocyte sedimentation rate; ICTP, C-terminal telopeptide of type I collagen; PICP, C-terminal propeptide of type I procollagen.