Table 4 Correlations between changes over 2 years in biochemical markers of bone and cartilage metabolism and in bone mineral density and radiographic joint destruction

ΔESR

ΔCTX-I

ΔICTP

ΔBSP

ΔPICP

ΔCTX-II

ΔCOMP

ΔBMD, forearm

ΔBMD, total hip

ΔBMD, lumbar spine

ΔLarsen score

ΔESR

-

0.276*

0.327**

0.004

-0.031

0.407***

0.188

-0.093

-0.092

-0.145

0.068

ΔCTX-I

0.276*

-

0.535***

0.189

0.348**

0.119

0.184

-0.234

-0.507***

-0.501***

0.083

ΔICTP

0.327**

0.535***

-

0.167

0.040

0.401**

0.338**

-0.239

-0.271*

-0.372**

-0.043

ΔBSP

0.004

0.189

0.167

-

-0.092

-0.029

0.004

-0.056

-0.163

0.032

-0.079

ΔPICP

-0.031

0.348**

0.040

-0.092

-

0.042

0.328**

-0.138

-0.266*

-0.222

0.392**

ΔCTX-II

0.407***

0.119

0.401**

-0.029

0.042

-

0.190

-0.094

-0.055

-0.146

0.052

ΔCOMP

0.188

0.184

0.338**

0.004

0.328**

0.190

-

-0.190

-0.204

-0.157

-0.027

ΔEstradiol

-0.079

-0.373**

-0.301*

-0.092

-0.160

-0.094

-0.243

0.067

0.491***

0.483***

0.063