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Table 4 Correlations between changes over 2 years in biochemical markers of bone and cartilage metabolism and in bone mineral density and radiographic joint destruction

From: Hormone replacement therapy, calcium and vitamin D3 versus calcium and vitamin D3alone decreases markers of cartilage and bone metabolism in rheumatoid arthritis: a randomized controlled trial [ISRCTN46523456]

  ΔESR ΔCTX-I ΔICTP ΔBSP ΔPICP ΔCTX-II ΔCOMP ΔBMD, forearm ΔBMD, total hip ΔBMD, lumbar spine ΔLarsen score
ΔESR - 0.276* 0.327** 0.004 -0.031 0.407*** 0.188 -0.093 -0.092 -0.145 0.068
ΔCTX-I 0.276* - 0.535*** 0.189 0.348** 0.119 0.184 -0.234 -0.507*** -0.501*** 0.083
ΔICTP 0.327** 0.535*** - 0.167 0.040 0.401** 0.338** -0.239 -0.271* -0.372** -0.043
ΔBSP 0.004 0.189 0.167 - -0.092 -0.029 0.004 -0.056 -0.163 0.032 -0.079
ΔPICP -0.031 0.348** 0.040 -0.092 - 0.042 0.328** -0.138 -0.266* -0.222 0.392**
ΔCTX-II 0.407*** 0.119 0.401** -0.029 0.042 - 0.190 -0.094 -0.055 -0.146 0.052
ΔCOMP 0.188 0.184 0.338** 0.004 0.328** 0.190 - -0.190 -0.204 -0.157 -0.027
ΔEstradiol -0.079 -0.373** -0.301* -0.092 -0.160 -0.094 -0.243 0.067 0.491*** 0.483*** 0.063
  1. Radiographic joint destruction was assessed using the Larsen score [27]. *P < 0.05; **P < 0.01; ***P < 0.001. BMD = bone mineral density; BSP, bone sialoprotein; COMP, cartilage oligomeric matrix protein; CTX-I, type I collagen C-telopeptide fragments; CTX-II, type II collagen C-telopeptide; ESR, erythrocyte sedimentation rate; ICTP, C-terminal telopeptide of type I collagen; PICP, C-terminal propeptide of type I procollagen.