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Table 2 Susceptibility to immunization with matrilin-1 in mice heterozygous or homozygous for an IL-10 gene deletion

From: Critical role of the major histocompatibility complex and IL-10 in matrilin-1-induced relapsing polychondritis in mice

Mice n Incidence (%) Mean maximum scorea Day of onset of symptoms
IL-10+/- 9 44 2.8 ± 0.8 68 ± 30
IL-10-/- 11 82 3.5 ± 1.4* 41 ± 6*
  1. All mice were bred on a C57BL/10 background carrying the H2qhaplotype in the MHC class II region. aScore of severity of matrilin-1-induced relapsing polychondritis, from a possible maximum of 5; see Materials and methods. *P < 0.05.