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Table 1 Diagnostic significance of anti-Sa in the rheumatic diseases

From: Insights into rheumatoid arthritis derived from the Sa immune system

   Total no. Rheumatoid    Positive predictive
Country Reference of patients patients Sensitivity (%) Specificity (%) value (%)
Canada [7] 482 206 43 99 97
Spain [17] 1087 360 33 100 99
France [3] 403 154 40 92 n/a
Austria [16] 247 46 37 98 n/a
China [18] 518 191 32 99 94
Total   2737 957 37 98 97
  1. The control populations were normal individuals and patients with degenerative arthritis from the communities shown, autoimmune patients with systemic lupus erythematosus, Sjögren and other systemic connective tissue diseases, and patients with chronic arthritis of the spondylarthropathy variants. All RA patients satisfied the ACR criteria, including those with early (less than 1 year) disease. It is important to note that the data on sensitivity, specificity and positive predictive value for RA are valid only for established RA cohorts and would not necessarily apply to early synovitis cohorts, where satisfying the ACR criteria for RA at entry is not a prerequisite. n/a, not applicable.