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Table 2 Comparisons of genetic variants in 143 patients with SLE and 200 healthy blood donors

From: Analysis of HLA DR, HLA DQ, C4A, FcγRIIa, FcγRIIIa, MBL, and IL-1Ra allelic variants in Caucasian systemic lupus erythematosus patients suggests an effect of the combined FcγRIIa R/R and IL-1Ra 2/2 genotypes on disease susceptibility

Genetic variant

Patients

Controls

   
 

No.

(%)

No.

(%)

P a

ORa

95% CIa

HLA DR3-DQ2-C4AQ0

61

(43)

42

(21)

<0.0001

2.8

1.7–4.5

FcγRIIa R/R

46

(32)

51

(26)

0.18

1.4

0.86–2.2

FcγRIIIa F/F

68

(48)

90

(45)

0.66

1.1

0.72–1.7

MBL-low

19

(13)

28

(14)

0.88

0.94

0.50–1.8

IL-1 Ra 2/2

14

(9.8)

14

(7.0)

0.42

1.4

0.66–3.1

HLA DR3-DQ2-C4AQ0 / FcγRIIa R/R

20

(14)

7

(3.5)

0.0005

4.5

1.8–10.9

HLA DR3-DQ2-C4AQ0 / FcγRIIIa F/F

29

(20)

19

(9.5)

0.007

2.4

1.3–4.5

HLA DR3-DQ2-C4AQ0 / MBL-low

11

(7.7)

5

(2.5)

0.04

3.3

1.1–9.6

HLA DR3-DQ2-C4AQ0 / IL-1 Ra 2/2

4

(2.8)

3

(1.5)

0.46

1.9

0.42–8.6

FcγRIIa R/R / FcγRIIIa F/F

31

(22)

32

(16)

0.20

1.5

0.84–2.5

FcγRIIa R/R / MBL-low

3

(2.1)

6

(3.0)

0.74

0.69

0.17–2.8

FcγRIIa R/R / IL-1 Ra 2/2

8

(5.6)

1

(0.5)

0.005

11.8

1.5–95.4

FcγRIIIa F/F / MBL-low

8

(5.6)

12

(6.0)

1.0

0.92

0.37–2.3

FcγRIIIa F/F / IL-1 Ra 2/2

8

(5.6)

4

(2.0)

0.13

2.9

0.86–9.8

MBL-low / IL-1 Ra 2/2

1

(0.7)

0

(0.0)

0.42

4.2

0.17–104

  1. aBold type indicates statistical significance (P <0.05); CI, confidence interval; F, phenylalanine; MBL, mannan-binding lectin; MBL-low, MBL genotype conferring a low serum concentration of MBL; OR, odds ratio; R, arginine.