Analysis of infection-induced immune responses in IL-27 receptor deficient mice. The availability of receptor deficient mice has allowed researchers to explore the role of IL-27 in vivo. This figure summarizes the immune response of WSX-1 -/- mice upon challenge with various prokaryotic and eukaryotic pathogens. References are listed as bracketed citations in the far right column of the figure. BCG, bacille Calmette-Guérin; IFN, interferon; IL, interleukin, TNF, tumor necrosis factor.