Cell-cell interactions in synovitis: Interactions between T cells and B cells in rheumatoid arthritis

Table 1 Features of secondary lymphoid tissues in lymph nodes and tertiary lymphoid tissues in rheumatoid synovium

Tissue	Lymph node primary follicles	Lymph node secondary follicles	Synovial CD23-null T-cell–B-cell aggregates	Synovial CD23^{+ follicles}
Organized T-cell zones	+	+	+	+
Follicular clustering of B cells	+	+	+	+
Proliferating B cells	-	+	-	+
Hypermutated immunoglobulin genes	-	+	?	+
Plasma cells with identical rearrangements	-	+	?	-
CD23⁺ FDC networks	+	-	-	+
CD8⁺CD40L⁺ cells	-	-	-	+

ISSN: 1478-6362