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Table 1 Features of secondary lymphoid tissues in lymph nodes and tertiary lymphoid tissues in rheumatoid synovium

From: Cell-cell interactions in synovitis: Interactions between T cells and B cells in rheumatoid arthritis

Tissue Lymph node primary follicles Lymph node secondary follicles Synovial CD23-null T-cell–B-cell aggregates Synovial CD23+ follicles
Organized T-cell zones + + + +
Follicular clustering of B cells + + + +
Proliferating B cells - + - +
Hypermutated immunoglobulin genes - + ? +
Plasma cells with identical rearrangements - + ? -
CD23+ FDC networks + - - +
CD8+CD40L+ cells - - - +