| |
Days after induction of ICA
|
|---|
| |
1
|
3
|
7
|
14
|
|---|
|
Mouse strain
|
Infiltrate
|
Exudate
|
Infiltrate
|
Exudate
|
Infiltrate
|
Exudate
|
Infiltrate
|
Exudate
|
|---|
|
FcRγ-/-
|
0.4 ± 0.1
|
0.3 ± 0.2
|
0.1 ± 0.1*
|
0.1 ± 0.1*
|
ND
|
ND
|
ND
|
ND
|
|
C57BL/6
|
1.4 ± 0.1
|
0.8 ± 0.2
|
1.4 ± 0.3
|
1.5 ± 0.4
|
1.2 ± 1.2
|
0.5 ± 0.6
|
0.4 ± 0.3
|
0
|
|
DBA/1
|
ND
|
ND
|
2.1 ± 0.2*
|
1.8 ± 0.3
|
3.0 ± 0*
|
2.5 ± 0.4*
|
2.1 ± 0.3*
|
1.6 ± 0.2*
|
- Cellular score in knee joints 3, 7, and 14 days after induction of ICA in knee joints of FcR γ-chain-/-, C57BL/6, and DBA/1 mice. The amount of inflammatory cells in the joint cavity (exudate) and in the synovial layer (infiltrate) were scored blind by two independent observers, on an arbitrary scale from 0-3 (0 = no; 1 = minor; 2 = moderate; 3 = maximal). Note that FcR γ-chain-/- mice show markedly less inflammation and that knee joints of DBA/1 mice were significantly more inflamed at all time points in comparison with C57BL/6 mice. Data are means of scores for six mice, and significance (FcR γ-chain-/- versus C57BL/6, and DBA/1 versus C57BL/6) was evaluated using the Mann-Whitney U test (*P < 0.05). ND, not done.
