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Table 1 Joint inflammation in FcR γ-chain-/-, wild-type C57BL/6, and DBA/1 mice

From: FcγR expression on macrophages is related to severity and chronicity of synovial inflammation and cartilage destruction during experimental immune-complex-mediated arthritis (ICA)

 

Days after induction of ICA

 

1

3

7

14

Mouse strain

Infiltrate

Exudate

Infiltrate

Exudate

Infiltrate

Exudate

Infiltrate

Exudate

FcRγ-/-

0.4 ± 0.1

0.3 ± 0.2

0.1 ± 0.1*

0.1 ± 0.1*

ND

ND

ND

ND

C57BL/6

1.4 ± 0.1

0.8 ± 0.2

1.4 ± 0.3

1.5 ± 0.4

1.2 ± 1.2

0.5 ± 0.6

0.4 ± 0.3

0

DBA/1

ND

ND

2.1 ± 0.2*

1.8 ± 0.3

3.0 ± 0*

2.5 ± 0.4*

2.1 ± 0.3*

1.6 ± 0.2*

  1. Cellular score in knee joints 3, 7, and 14 days after induction of ICA in knee joints of FcR γ-chain-/-, C57BL/6, and DBA/1 mice. The amount of inflammatory cells in the joint cavity (exudate) and in the synovial layer (infiltrate) were scored blind by two independent observers, on an arbitrary scale from 0-3 (0 = no; 1 = minor; 2 = moderate; 3 = maximal). Note that FcR γ-chain-/- mice show markedly less inflammation and that knee joints of DBA/1 mice were significantly more inflamed at all time points in comparison with C57BL/6 mice. Data are means of scores for six mice, and significance (FcR γ-chain-/- versus C57BL/6, and DBA/1 versus C57BL/6) was evaluated using the Mann-Whitney U test (*P < 0.05). ND, not done.
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Arthritis Research & Therapy

ISSN: 1478-6362

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