|
During ICA
|
During ZIA
|
---|
|
IL-1Ra
|
IL-1β
|
IL-1β
|
---|
Mouse strain
|
At 6 h
|
At 6 h
|
At 24 h
|
At 6 h
|
At 24 h
|
---|
FcRγ-/-
|
180 ± 15
|
200 ± 23
|
<20*
|
ND
|
ND
|
C57BL/6
|
215 ± 20
|
240 ± 21
|
70 ± 12
|
>1000
|
550 ± 30
|
DBA/1
|
ND
|
390 ± 43*
|
120 ± 15*
|
>1000
|
565 ± 5
|
- Production of IL-1Ra at 6 h and IL-1β at 6 and 24 h after induction of ICA and ZIA in knee joints of three mouse strains. IL-1β was measured using a radioimmunoassay. Data are means ± SD of at least 5 mice and were evaluated using the Mann-Whitney U test (*P < 0.05). ICA, immune-complex-mediated arthritis; IL-1Ra, IL-1 receptor antagonist; ND = not done; ZIA, zymosan-induced arthritis.