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Table 2 IL-1 and IL-1Ra production (pg/ml) in knee joints of mice after induction of immune-complex-mediated arthritis (ICA) and zymosan-induced arthritis (ZIA)

From: FcγR expression on macrophages is related to severity and chronicity of synovial inflammation and cartilage destruction during experimental immune-complex-mediated arthritis (ICA)

 

During ICA

During ZIA

 

IL-1Ra

IL-1β

IL-1β

Mouse strain

At 6 h

At 6 h

At 24 h

At 6 h

At 24 h

FcRγ-/-

180 ± 15

200 ± 23

<20*

ND

ND

C57BL/6

215 ± 20

240 ± 21

70 ± 12

>1000

550 ± 30

DBA/1

ND

390 ± 43*

120 ± 15*

>1000

565 ± 5

  1. Production of IL-1Ra at 6 h and IL-1β at 6 and 24 h after induction of ICA and ZIA in knee joints of three mouse strains. IL-1β was measured using a radioimmunoassay. Data are means ± SD of at least 5 mice and were evaluated using the Mann-Whitney U test (*P < 0.05). ICA, immune-complex-mediated arthritis; IL-1Ra, IL-1 receptor antagonist; ND = not done; ZIA, zymosan-induced arthritis.