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Table 1 Cytokine involvement in various experimental arthritis models

From: Anti-cytokine therapy in chronic destructive arthritis

    

Cytokine involvement

    

Early inflammation

Erosive arthritis

Arthritis Model

Species

References

Principal target or trigger

TNF

IL-1

TNF

IL-1

SCW-A

Mouse

[32]

Macrophages

++

-

-

++

SCW flare

Mouse

[33]

T cells/macrophages

+

+

-

++

SCW flare

Rat

[46,77]

T cells/macrophages

+

+

 

++

AIA

Mouse

[35,36,38]

T cells/IC

±

±

 

++

AIA

Rabbit

[37]

T cells/IC

+

+

±

++

AIA flare

Mouse

[38]

T cells

±

+

-

++

CIA

Mouse

[6,7,8,9,10,11]

T cells/IC

+

++

+*

++

ICA

Mouse

[40]

IC

-

++

-

++

AA

Rat

[45]

T cells

+

+

+*

+

  1. Cytokine involvement, based on experiments with neutralizing antibodies, started at the onset of arthritis. It does not reflect potential involvement during preimmunization (CIA and AIA). SCW-A flares reflect the situation after three consecutive SCW flares with intervals of 7 days. AIA flare was induced by antigen rechallenge at day 21. CIA, collagen-induced arthritis; ICA, passive immune complex (IC) arthritis. *Efficacy of anti-TNF treatment only when started at onset of first signs of arthritis.
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Arthritis Research & Therapy

ISSN: 1478-6362

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