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Figure 2 | Arthritis Research & Therapy

Figure 2

From: Role of IL-12 in Staphylococcus aureus-triggered arthritis and sepsis

Figure 2

Effect of IL-12 on staphylococcal growth in vivo. (a) Bacterial growth in the liver, at days 2, 7 and 20 after staphylococcal inoculation. At day 2, n = 5 in each group; at day 7, n = 6 IL-12-deficient mice and 5 control animals; and at day 20, n = 8 IL-12-/- mice and 9 wild-type controls. (b) Bacterial growth in the kidneys, at days 2, 7 and 20 after staphylococcal inoculation. At day 2, n = 5 in each group; at day 7, n = 6 IL-12-deficient mice and 5 control animals; and at day 20, n = 8 IL-12-/- mice and 9 wild-type controls. (c) Frequency of mice with bacterial growth in the joints, at days 2, 7 and 20 after staphylococcal inoculation. At day 2, n = 5 in each group; at day 7, n = 6 IL-12-deficient mice and 5 control animals; and at day 20, n = 8 IL-12-/- mice and 9 wild-type controls. Fifteen CFU was regarded as a positive staphylococcal growth. (d) Bacterial growth in blood, 6 h after staphylococcal inoculation; n = 5 for both IL-12+/+ and IL-12-/-.

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