Serum cartilage oligomeric matrix protein (COMP) level as a markerof cartilage turnover. Suppression of serum COMP was found after treatment withinterleukin (IL)-4 and IL-4/prednisolone (Pred). IL-4(1 μg/day) and bothdoses (0.1 μg per day/0.05 mg per kg per day; and 1 μg perday/0.05 mg per kg per day) of IL-4/prednisolone reduced serum COMP levels tobasic levels as found in nonimmunized animals (4.2 ± 0.2 μg/ml). Thedata represent the mean± standard deviation COMP level of at least sixsera per group. *P < 0.01, versus vehicle, byMann-Whitney U test.