Protection of interleukin (IL)-4 and IL-4/prednisolone (Pred)treatment on bone destruction. Knee joints were isolated at day 35 and bonedestruction was examined by radiographic analysis. For treatment scheme seeFig. 2. Erosions were scored on a scale ranging from 0 to5 on the femur head, tibia and patella. Each group consists of at least nineknee joints per group. *P < 0.01, versus vehicle, byMann-Whitney U test.