Interleukin (IL)-4 or IL-4/prednisolone (Pred) treatment isassociated with reduced anticollagen type II (CII) antibody levels. Treatmentwith 1 μg/day IL-4 resulted in lower anticollagen type II antibodies.Total Immunoglobulins (Ig tot), IgG1 and IgG2a levelswere reduced. Similar effects were found after treatment with IL-4/prednisolone(1 μg per day/0.05 mg per kg). Anticollagen type II levels were determinedin at least six mice per group. Data are expressed as means ± standarddeviation dilution, which gives the half maximal value.