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Figure 9 | Arthritis Research & Therapy

Figure 9

From: Protection against cartilage and bone destruction by systemic interleukin-4 treatment in established murine type II collagen-induced arthritis

Figure 9

Interleukin (IL)-4 or IL-4/prednisolone (Pred) treatment isassociated with reduced anticollagen type II (CII) antibody levels. Treatmentwith 1 μg/day IL-4 resulted in lower anticollagen type II antibodies.Total Immunoglobulins (Ig tot), IgG1 and IgG2a levelswere reduced. Similar effects were found after treatment with IL-4/prednisolone(1 μg per day/0.05 mg per kg). Anticollagen type II levels were determinedin at least six mice per group. Data are expressed as means ± standarddeviation dilution, which gives the half maximal value.

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