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Table 2 Serum interleukin-1 receptor antagonist (IL-1Ra levels) after treatment with either interleukin (IL)-4, prednisolone, or IL-4/prednisolone

From: Protection against cartilage and bone destruction by systemic interleukin-4 treatment in established murine type II collagen-induced arthritis

Treatment Dose IL-1Ra (pg/ml)
Vehicle - 414 ± 155
IL-4 0.1 386 ± 213
IL-4 1 838 ± 187*
Prednisolone 0.05 326 ± 165
IL-4/prednisolone 0.1/0.05 422 ± 129
  1/0.05 499 ± 187
  1. Serum IL-1Ra was determined using enzyme-linked immunosorbentassay at day 35 after immunization. Mice were treated as indicated in Table1. The data represent the mean± standard deviationof at least eight mice per group. The sensitivity of the IL-1Ra assay was towithin 160 pg/ml. *P < 0.05, versus vehicle, byMann-Whitney U test.