Figure 2

Expression of hsp70 (a) and phosphorylated p38 protein kinase (b) in the synovial-lining layer. Immunohistochemistry of synovial membranes of patients with RA shows a hypertrophic synovial-lining layer. (a) Immunostaining for heat shock protein (HSP)70; (b) staining for phosphorylated p38 protein kinase (brown). Both molecules show strong expression in the synovial-lining layer of patients with RA.