Table 1 The IL-17 superfamily: cellular sources, receptors, and major functions
Cytokine | Other names | Cellular source | Receptor | Major functions |
|---|---|---|---|---|
IL-17 | IL-17A, CTLA-8 | T cells (memory) | IL-17R (also known as, IL-17AR) | Inflammation, neutrophil recruitment, cytokine secretion, bone metabolism |
IL-17B | Multiple organs | IL-17BR (also known as, IL-17Rh1/Evi27) | Cytokine secretion, inflammation | |
IL-17C | Unknown | Unknown | Regulation of Th1 cytokines | |
IL-17D | IL-27 | Multiple organs | Unknown | Cytokine secretion |
IL-17E | IL-25 | Th2 | IL-17BR (also known as, IL-17Rh1/Evi27) | Regulation of Th2 cytokines |
IL-17F | ML-1 | CD4+ T cells and monocytes | IL-17R? | Angiogenesis, cytokine secretion, regulation of Th1 cytokines |
HVS13 | vIL-17 | Herpesvirus saimiri infected cells | IL-17R? | Unknown (not required for cellular transformation) |