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Table 2 p53 mutations in paired rheumatoid arthritis (RA) fibroblast-like synoviocytes and synovial tissue samples

From: p53tumor suppressor gene mutations in fibroblast-like synoviocytes from erosion synovium and non-erosion synovium in rheumatoid arthritis

Patient Fibroblast-like synoviocytes Synovial tissue
  Mutation Frequency Mutation Frequency
RA10 Codon 119 GCC>ACC (Ala>Thr) 1/10 Codon 196 CGA>TGA (Arg>stop) 1/12
  Codon 178 CAC>AC (deletion) 1/10   
  Codon 223 CCT>CAT (Pro>His) 1/10   
  Codon 360 GGG>AGG (Gly>Arg) 1/10   
  Long deletion codon 143 – codon 220 1/10   
  Codon 213 CGA>CGG (Arg>Arg) 5/10a Codon 213 CGA>CGG (Arg>Arg) 6/12
RA11 Codon 307 GCA>GCT (Ala>Ala) 2/9 Codon 147 GTT>ATT (Val>IIe) 1/12
  Deletion codon 304 – codon 337 1/9 Codon 225 GTT>GTG (Val>Val) 1/12
RA12 Codon 355 GCT>GCC (Ala>Ala) 1/12 Codon 213 CGA>CAA (Arg>Gln) 1/11
    Codon 213 CGA>CGG (Arg>Arg) 1/11
    Codon 269 AGC>AAC (Ser>Asn) 1/11
RA13 Codon 134 TTT>CTT (Phe>Leu) 1/12 None 0/11
  Codon 216 GTG>ATG (Val>Met) 1/12   
  Codon 249 AGG>GGG (Arg>Gly) 3/12   
  1. Data presented as number of mutant subclones/total number of subclones analyzed. Nested PCR required for RA12 and RA13 FLS and RA10 – RA13 synovial tissues. a Recognized p53 polymorphism also detected in normal peripheral blood mononuclear cells (most probably germline).