Table 3 p53 mutation clusters identified in greater than one subclone isolated from rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) or from synovial tissue
p53 mutation | Origin | Reference |
|---|---|---|
Codon 138 GCC>GTC (Ala>Val) | Microdissected synovial tissue | [9] |
Deletion codon 143 – codon 220 | Microdissected synovial tissue | [9] |
Codon 144 CAG>TAG (Gly>stop) | Microdissected synovial tissue | [9] |
Codon 176 TGC>CGC (Cys>Arg) | Microdissected synovial tissue | [9] |
Codon 213 CGA>TGA (Arg>stop) | Microdissected synovial tissue | [9] |
Codon 245 GGC>GAC (Gly>Asp) | Cultured FLS | [23] |
Codon 249 AGG>GGG (Arg>Gly) | Cultured FLS | Present study |
Codon 300 CCC>TCC(Pro>Ser) | Microdissected synovial tissue | [9] |
Codon 307 GCA>GCT (Ala>Ala) | Cultured FLS | Present study |
Codon 321 AAA>GAA (Lys>Glu) | Cultured FLS | Present study |
Codon 337 CGC>AGC (Arg>Ser) | Microdissected synovial tissue | [9] |