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Table 3 p53 mutation clusters identified in greater than one subclone isolated from rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) or from synovial tissue

From: p53tumor suppressor gene mutations in fibroblast-like synoviocytes from erosion synovium and non-erosion synovium in rheumatoid arthritis

p53 mutation Origin Reference
Codon 138 GCC>GTC (Ala>Val) Microdissected synovial tissue [9]
Deletion codon 143 – codon 220 Microdissected synovial tissue [9]
Codon 144 CAG>TAG (Gly>stop) Microdissected synovial tissue [9]
Codon 176 TGC>CGC (Cys>Arg) Microdissected synovial tissue [9]
Codon 213 CGA>TGA (Arg>stop) Microdissected synovial tissue [9]
Codon 245 GGC>GAC (Gly>Asp) Cultured FLS [23]
Codon 249 AGG>GGG (Arg>Gly) Cultured FLS Present study
Codon 300 CCC>TCC(Pro>Ser) Microdissected synovial tissue [9]
Codon 307 GCA>GCT (Ala>Ala) Cultured FLS Present study
Codon 321 AAA>GAA (Lys>Glu) Cultured FLS Present study
Codon 337 CGC>AGC (Arg>Ser) Microdissected synovial tissue [9]