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Table 2 Genes upregulated in ankle joints from SCW-induced arthritis in Lewis (LEW/N) rats

From: Gene expression profiles in the rat streptococcal cell wall-induced arthritis model identified using microarray analysis

Accession no.

Gene name

Day -13.8

Day -13

Day 3

C

I

  

Delta

P

Delta

P

Delta

P

  

Angiogenesis

NM_030985

AGTR1

_

_

_

_

4.0

2.3E-05

7

L

AI639162

ANGPT1

_

_

_

_

1.8

8.5E-08

7

L

NM_031012

ANPEP

_

_

_

_

2.2

2.9E-18

7

M

AI101782

COL18A1

_

_

_

_

2.9

6.3E-26

7

L

AI170324

FIGF

_

_

1.6

9.4E-04

2.4

4.6E-11

6

L

NM_012620

SERPINE1

6.6

2.3E-06

_

_

27.6

0.0E+00

4

L

Cell adhesion

NM_012830

CD2

_

_

2.1

2.9E-04

_

_

3

L

NM_054001

CD36L2

_

_

_

_

2.6

5.4E-05

7

L

AF065147

CD44

2.1

2.1E-08

1.6

1.1E-03

_

_

2

M

BE108345

COL12A1

_

_

_

_

2.5

4.6E-43

7

M

AI172281

COL5A2

_

_

_

_

2.0

9.3E-06

7

H

NM_021760

COL5A3

_

_

_

_

3.1

6.9E-27

7

M

AF084544

CSPG2

2.3

2.4E-03

2.1

5.8E-04

8.9

7.2E-37

5

L

NM_053719

EMB

_

_

_

_

3.5

1.7E-19

7

L

NM_053634

FCNB

8.7

3.0E-28

8.0

1.1E-17

29.0

0.0E+00

5

M

AI236745

GALNT1

_

_

_

_

2.9

0.0E+00

7

L

NM_133298

GPNMB

_

_

2.2

3.6E-12

2.5

0.0E+00

6

H

NM_012967

ICAM1

8.9

0.0E+00

4.4

7.2E-09

4.0

2.2E-11

5

L

AF268593

ITGAM

2.0

2.6E-03

3.8

1.7E-15

6.4

3.3E-18

5

L

BI296880

ITGB3

1.5

7.0E-03

_

_

2.1

2.3E-03

4

L

AF003598

ITGB7

2.0

8.9E-14

1.6

1.2E-03

1.9

1.1E-06

5

L

U56936

KLRB1B

_

_

_

_

3.0

6.4E-03

7

L

NM_022393

MGL

_

_

2.1

7.3E-08

2.1

2.3E-11

6

L

U72660

NINJ1

_

_

_

_

1.8

6.6E-28

7

M

BE097805

PCDHGC3

_

_

1.8

3.0E-03

_

_

3

L

AJ299017

RET

_

_

_

_

2.8

1.6E-08

7

L

AF071495

SCARB1

_

_

_

_

1.8

6.9E-03

7

L

L25527

SELE

_

_

3.1

3.6E-04

_

_

3

L

D10831

SELL

1.6

9.3E-05

_

_

1.8

6.9E-06

4

L

BI296054

SELP

1.8

7.1E-08

1.9

2.6E-07

2.2

4.2E-13

5

L

AI176034

TNC

_

_

_

_

2.6

3.7E-26

7

M

AF159103

TNFIP6

2.2

6.2E-04

2.2

3.1E-05

5.0

1.3E-21

5

L

NM_031590

WISP2

_

_

_

_

2.6

0.0E+00

7

M

Chemotaxis

NM_053619

C5AR1

1.6

5.0E-06

2.4

9.6E-21

2.7

2.8E-32

5

M

NM_019205

CCL11

3.9

2.3E-03

3.7

2.3E-07

_

_

2

L

NM_057151

CCL17

2.2

1.1E-05

_

_

_

_

1

L

AF053312

CCL20

8.3

7.3E-19

10.2

2.8E-10

15.5

3.5E-32

5

L

U22414

CCL3

15.3

1.7E-19

3.2

3.8E-05

2.1

1.1E-08

5

L

U06434

CCL4

6.0

1.5E-17

_

_

_

_

1

L

NM_031116

CCL5

_

_

2.6

5.9E-11

2.0

1.1E-03

6

L

NM_020542

CCR1

5.2

1.4E-15

2.1

3.0E-05

2.1

3.2E-03

5

L

NM_021866

CCR2

5.1

2.7E-07

3.3

2.9E-05

6.9

2.7E-13

5

L

NM_053960

CCR5

6.2

4.3E-19

6.0

1.8E-09

6.0

1.4E-10

5

L

D87927

CINC2

3.5

7.0E-03

_

_

_

_

1

L

AF253065

CKLF1

3.3

6.3E-09

3.0

2.7E-07

8.2

8.6E-08

5

L

NM_022218

CMKLR1

_

_

2.5

3.4E-03

_

_

3

L

U22520

CXCL10

3.2

4.4E-09

2.5

9.0E-03

1.4

1.3E-03

5

L

NM_053647

CXCL2

38.7

1.6E-07

2.3

9.1E-03

2.6

1.0E-03

5

L

NM_022214

CXCL6

2.2

2.3E-04

_

_

7.5

3.2E-06

4

L

NM_017183

CXCR2

10.6

1.5E-07

3.6

1.3E-03

_

_

2

L

NM_053415

CXCR3_V1

_

_

_

_

1.9

9.5E-04

7

L

AA945737

CXCR4

1.6

1.7E-03

1.7

3.9E-04

3.4

2.7E-15

5

L

NM_030845.1

GRO

17.1

0.0E+00

23.0

2.4E-04

19.8

1.8E-12

5

L

NM_053321

PTAFR

_

_

2.5

2.0E-03

_

_

3

L

NM_031530

SCYA2

3.4

6.0E-26

3.2

1.8E-16

6.0

0.0E+00

5

M

Complement activation

D88250

C1S

_

_

1.6

4.4E-03

1.8

7.5E-22

6

M

_

C2

6.9

9.20E-42

3.5

1.28E-11

16.8

0.0E+00

5

L

NM_016994.1

C3

2.7

2.0E-10

3.0

5.4E-12

10.4

0.0E+00

5

L

AI169829

MASP1

_

_

_

_

2.4

8.5E-08

7

L

Immune response/inflammatory response

XM_215303

RT1.S3

_

_

2.0

0.0012

1.6

1.5E-03

6

L

AF307302

BTNL2

_

_

2.1

1.0E-15

3.2

0.0E+00

6

M

NM_021744

CD14

2.8

7.8E-18

2.0

4.4E-06

1.7

7.3E-05

5

M

NM_012705

CD4

_

_

_

_

1.8

1.3E-07

7

L

NM_013069

CD74

_

_

2.2

3.5E-18

2.7

1.1E-31

6

H

NM_031538

CD8a

_

_

9.5

2.7E-03

10.9

6.2E-07

6

L

BI282755

EDG3

_

_

_

_

2.1

5.9E-03

7

L

X73371

FCGR2

3.1

1.4E-20

3.8

2.4E-08

6.5

0.0E+00

5

L

NM_053843

FCGR3

2.2

3.3E-15

2.0

2.8E-12

2.6

0.0E+00

5

M

NM_133624

GBP2

3.4

6.2E-35

_

_

1.5

3.8E-06

4

L

AF176534

HFE

_

_

_

_

1.8

6.6E-03

7

L

XM_215347

HLA-DMA

_

_

2.0

1.22E-14

2.7

0.0E+00

6

L

_

HLA-DMB

_

_

2.0

5.42E-15

3.2

1.1E-13

6

M

NM_022605

HPSE

_

_

_

_

1.9

3.0E-09

7

L

NM_133533

IGB

_

_

_

_

2.9

8.4E-09

7

L

NM_053374

IGIFBP

_

_

2.2

7.2E-03

_

_

3

L

AJ245643

IL1a

2.7

1.2E-03

_

_

_

_

1

L

NM_031512

IL1b

22.0

1.1E-30

9.5

4.5E-15

5.7

1.6E-35

5

L

NM_053953

IL1R2

2.5

1.9E-15

_

_

_

_

1

L

NM_022194

IL1RN

7.4

2.8E-03

_

_

_

_

1

L

NM_012589

IL6

10.0

7.3E-17

20.7

7.9E-04

21.4

5.5E-17

5

L

NM_013110

IL7

_

_

_

_

2.8

2.4E-04

7

L

NM_012591

IRF1

2.9

4.7E-13

2.6

2.8E-08

3.3

2.0E-13

5

L

NM_130741

LCN2

2.4

1.7E-09

3.4

9.8E-12

13.2

0.0E+00

5

M

BF282471

LCP2

2.6

2.2E-04

3.3

2.4E-04

6.2

4.4E-06

5

L

NM_022634

LST1

4.9

6.2E-14

6.3

6.4E-14

16.7

2.0E-36

5

L

NM_031634

MEFV

2.7

1.9E-07

_

_

1.9

7.4E-05

4

L

X52711

MX1

_

_

2.8

4.9E-07

1.9

2.1E-15

6

L

NM_134350

MX2

_

_

2.9

5.9E-04

_

_

3

L

NM_053734

NCF1

_

_

2.0

9.4E-16

2.0

3.7E-06

6

L

AA858801

NFKB1

2.1

1.1E-12

_

_

_

_

1

M

AW672589

NFKBIA

2.5

5.2E-36

_

_

_

_

1

M

L12562

NOS2A

6.0

1.9E-05

_

_

_

_

1

L

Z18877

OAS1

1.6

8.4E-06

2.4

3.8E-06

1.8

3.7E-06

5

L

NM_053288

ORM1

_

_

2.0

7.0E-04

3.1

9.8E-19

6

L

NM_031713

PIRB

2.4

3.9E-06

2.5

2.6E-06

3.3

7.6E-10

5

L

AF349115

PPBP

_

_

_

_

3.2

8.5E-03

7

L

NM_080767

PSMB8

1.5

3.0E-03

2.3

2.0E-09

3.3

0.0E+00

5

L

AI599350

PSMB9

2.0

2.0E-07

2.1

7.4E-09

3.7

2.3E-25

5

L

AB048730

PTGES

8.2

8.1E-40

3.9

1.0E-04

2.4

6.7E-04

5

L

NM_012645

RT1Aw2

_

_

3.3

0.000334

5.4

2.7E-10

6

L

X57523.1

TAP1

1.6

2.8E-04

1.6

9.8E-03

2.4

5.6E-07

5

L

NM_021578

TGFB1

_

_

2.1

8.4E-06

2.6

1.7E-10

6

L

AA819227

TNF

11.1

1.3E-27

2.5

1.9E-04

_

_

2

L

BM390522

TNFRSF1b

14.3

8.2E-19

3.7

4.2E-06

8.0

3.5E-06

5

L

NM_012759

VAV1

4.6

7.1E-05

7.6

1.2E-07

10.8

1.2E-12

5

L

Proteolysis and peptidolysis

NM_024400

ADAMTS1

3.1

9.2E-16

2.1

7.0E-04

3.5

1.3E-16

5

L

AA849399

CTSZ

1.6

6.4E-08

1.5

8.9E-12

3.4

1.6E-33

5

M

NM_012582

HP

2.1

4.8E-20

_

_

1.7

5.5E-05

4

L

NM_031670

KDAP

18.8

8.7E-23

6.6

5.0E-07

48.2

2.3E-37

5

L

AF154349

LGMN

_

_

2.1

1.8E-06

2.8

0.0E+00

6

M

NM_053963

MMP12

_

_

4.1

8.6E-05

7.7

8.2E-13

6

L

M60616.1

MMP13

_

_

_

_

2.0

4.7E-08

7

M

X83537

MMP14

_

_

_

_

1.8

2.1E-17

7

H

NM_053606

MMP23A

_

_

_

_

2.1

1.6E-11

7

L

NM_133523

MMP3

2.9

5.7E-29

2.7

1.4E-12

9.3

0.0E+00

5

H

AI102069

NSF

_

_

1.7

8.1E-03

1.8

3.9E-04

6

L

BF549923

PCSK5

_

_

1.8

1.5E-03

3.4

7.5E-21

6

L

X63434

PLAU

_

_

_

_

1.8

2.9E-14

7

M

AF007789

PLAUR

6.2

4.6E-04

_

_

4.9

7.2E-03

4

L

NM_053372

SLPI

2.6

8.3E-09

2.6

5.4E-22

7.0

0.0E+00

5

M

NM_053819

TIMP1

2.2

0.0E+00

1.8

5.9E-09

6.4

0.0E+00

5

H

NM_053299

UBD

_

_

_

_

4.7

9.1E-04

7

L

Signal transduction

NM_019285

ADCY4

_

_

_

_

2.3

3.5E-05

7

L

BF285345

ARRB2

_

_

1.8

2.5E-05

2.5

6.5E-20

6

L

NM_057196

BAIAP2

_

_

4.4

5.5E-03

_

_

3

L

NM_012766

CCND3

_

_

_

_

2.1

6.0E-08

7

L

NM_013169

CD3d

_

_

_

_

3.9

3.7E-07

7

L

AF065161

CISH

2.5

1.1E-03

_

_

_

_

1

L

NM_031352

DBNL

_

_

1.7

6.6E-11

1.8

1.2E-04

6

L

BI278868

EPIM

_

_

_

_

2.1

6.7E-03

7

L

NM_024147

EVL

_

_

_

_

3.6

8.0E-09

7

L

L02530

FZD2

_

_

_

_

3.3

6.3E-07

7

L

NM_030829.1

GPRK5

_

_

_

_

2.0

1.0E-04

7

L

U87863.1

HGS

_

_

1.9

3.6E-03

_

_

3

L

AY044251

IL13RA1

_

_

_

_

3.2

3.0E-08

7

L

AI178808

IL2RG

2.4

8.1E-14

2.5

10.0E-23

5.6

0.0E+00

5

L

NM_133380

IL4R

_

_

6.5

4.8E-05

7.5

3.4E-18

6

L

NM_017020

IL6R

_

_

1.8

2.4E-10

1.8

1.6E-12

6

L

NM_019311

INPP5D

_

_

_

_

1.9

7.9E-20

7

L

NM_012798

MAL

2.1

1.9E-04

_

_

_

_

1

L

AW533194

MAPK10

2.4

5.7E-03

_

_

_

_

1

L

AF411318

MT1A

2.6

2.4E-27

2.4

2.2E-04

3.4

6.0E-34

5

M

NM_012613

NPR1

_

_

_

_

3.3

1.9E-03

7

L

U32497

P2RX4

_

_

1.6

4.2E-15

1.9

2.5E-20

6

L

AF202733

PDE4B

2.4

1.1E-07

2.5

8.1E-04

2.3

2.5E-03

5

L

BE099769

PLAA

_

_

2.5

8.7E-03

_

_

3

L

X04440

PRKCB1

_

_

_

_

1.8

3.3E-08

7

L

AF254800

RAB0

_

_

_

_

1.9

7.8E-04

7

L

NM_019250

RALGDS

1.9

8.1E-05

_

_

_

_

1

L

NM_021661

RGS19

_

_

_

_

1.8

1.8E-05

7

L

AF321837

RGS2

_

_

_

_

2.3

2.4E-09

7

L

NM_053338

RRAD

7.0

5.2E-05

4.8

1.6E-05

4.0

6.5E-03

5

L

BE117558

SFRP1

_

_

_

_

1.8

2.4E-08

7

M

BF389682

SOCS3

3.8

0.0E+00

2.0

1.2E-05

3.6

3.2E-33

5

L

NM_022230

STC2

_

_

3.1

2.2E-03

_

_

3

L

BG668493

STMN2

_

_

2.3

2.6E-06

14.0

7.2E-42

6

L

U21683

SYK

_

_

_

_

1.8

2.1E-05

7

L

  1. Genes upregulated (Delta > 1.8 and P < 0.01) on days -13.8 (4 hours after intra-articular injection of streptococcal cell wall [SCW]), -13 and 3 are grouped by their general ontology and clustered based on their similarity in terms of pattern of expression (C) and expression level (I). Data are expressed as the mean fold increase in gene expression (Delta) in SCW-injected animals as compared with expression in the corresponding phosphate-buffered saline (PBS) control group (four to five animals/group), along with the P value. C, number of clusters to which the gene corresponds (trend plots are given in Fig. 6); I, intensity of gene expression (L = low intensity [0–500], M = medium intensity [500–1500], H = high intensity [1500–4000]). A line (_) in the Delta or P cell indicates that the gene was not found to be differentially expressed at that particular time point.
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Arthritis Research & Therapy

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