Gene expression profiles in the rat streptococcal cell wall-induced arthritis model identified using microarray analysis

Table 3 Upregulated genes (Delta > 5, P < 0.01) not previously reported to be associated with arthritis

Accession no.	Gene	Delta	Rat CL	Rat QTLs	Human CL	Human QTLs
NM_178144	AMIGO3	Nd/Nd/5.9	8q32	Cia6	3p21.31	Asthma
NM_130411	CORO1A	3.1/2.7/6.6	1q36	Pia11	16p12.1	Blau syndrome, asthma
NM_024381	GYK	6.7/Nd/Nd	Xq22	Cia19	Xp21.3	Allergic rhinitis
NM_031670	KDAP	18.8/6.6/48.2	1q22	_	19q13.3	Asthma, SLE, MS, SD
NM_569105	LCP2	2.6/3.3/6.2	10q12	Cia16, Pia15	5q33.1	RA, PDB, asthma, IBD, psoriasis, ATD
NM_021586	LTBP2	Nd/Nd/6.5	6q31	Pia3, Pia24	14q24	SLE, MODY3
NM_198746	Ly-49.9	Nd/2.0/5.6	4q42	Cia13, Cia24, Pia7, Pia23, Oia2, Oia7, Oia8, Ciaa4	12p13-p12	RA, allergic rhinitis, hypophosphataemic rickets
NM_022667	MATR1	1.7/1.9/5.7	8q32	Cia6	3q21	Atopic dermatitis, asthma, psoriasis
NM_133306	OLR1	8.3/2.8/3.7	4q42	Cia13, Cia24, Pia7, Pia23, Oia2, Oia7, Oia8, Ciaa4	12p13.2-p12.3	RA, hypophosphataemic rickets, allergic rhinitis
NM_053687	SLFN4	5.8/4.6/4.8	10q26	Cia16, Cia21, Cia22, Cia23, Oia4, Ciaa2	17q11.2-q21.1	SLE, MS

The rat chromosomal location and the chromosomal locations of the corresponding human orthologue were identified and mapped to quantitative trait loci (QTLs) previously associated with inflammation, arthritis and/or other autoimmune diseases. Delta values are given for the following time points: day -13.8/day -13/day 3. ATD, autoimmune thyroid disease; CIA, type II collagen-induced arthritis; Ciaa, CIA autoantibody; CL, chromosome location; IBD, inflammatory bowel disease; MOYD 3, maturity-onset diabetes of the young 3; MS, multiple sclerosis; Nd, not differentially expressed; Oia, oil-induced arthritis; PDB, Paget's disease of bone; PIA, pristane-induced arthritis; RA, rheumatoid arthritis; SD, spondylocostal dysostosis; SLE, systemic lupus erythematosus.

ISSN: 1478-6362