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Table 3 Upregulated genes (Delta > 5, P < 0.01) not previously reported to be associated with arthritis

From: Gene expression profiles in the rat streptococcal cell wall-induced arthritis model identified using microarray analysis

Accession no. Gene Delta Rat CL Rat QTLs Human CL Human QTLs
NM_178144 AMIGO3 Nd/Nd/5.9 8q32 Cia6 3p21.31 Asthma
NM_130411 CORO1A 3.1/2.7/6.6 1q36 Pia11 16p12.1 Blau syndrome, asthma
NM_024381 GYK 6.7/Nd/Nd Xq22 Cia19 Xp21.3 Allergic rhinitis
NM_031670 KDAP 18.8/6.6/48.2 1q22 _ 19q13.3 Asthma, SLE, MS, SD
NM_569105 LCP2 2.6/3.3/6.2 10q12 Cia16, Pia15 5q33.1 RA, PDB, asthma, IBD, psoriasis, ATD
NM_021586 LTBP2 Nd/Nd/6.5 6q31 Pia3, Pia24 14q24 SLE, MODY3
NM_198746 Ly-49.9 Nd/2.0/5.6 4q42 Cia13, Cia24, Pia7, Pia23, Oia2, Oia7, Oia8, Ciaa4 12p13-p12 RA, allergic rhinitis, hypophosphataemic rickets
NM_022667 MATR1 1.7/1.9/5.7 8q32 Cia6 3q21 Atopic dermatitis, asthma, psoriasis
NM_133306 OLR1 8.3/2.8/3.7 4q42 Cia13, Cia24, Pia7, Pia23, Oia2, Oia7, Oia8, Ciaa4 12p13.2-p12.3 RA, hypophosphataemic rickets, allergic rhinitis
NM_053687 SLFN4 5.8/4.6/4.8 10q26 Cia16, Cia21, Cia22, Cia23, Oia4, Ciaa2 17q11.2-q21.1 SLE, MS
  1. The rat chromosomal location and the chromosomal locations of the corresponding human orthologue were identified and mapped to quantitative trait loci (QTLs) previously associated with inflammation, arthritis and/or other autoimmune diseases. Delta values are given for the following time points: day -13.8/day -13/day 3. ATD, autoimmune thyroid disease; CIA, type II collagen-induced arthritis; Ciaa, CIA autoantibody; CL, chromosome location; IBD, inflammatory bowel disease; MOYD 3, maturity-onset diabetes of the young 3; MS, multiple sclerosis; Nd, not differentially expressed; Oia, oil-induced arthritis; PDB, Paget's disease of bone; PIA, pristane-induced arthritis; RA, rheumatoid arthritis; SD, spondylocostal dysostosis; SLE, systemic lupus erythematosus.