Table 2 Down-regulated genes in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLSs) stimulated with protein I/II. Confluent RA FLSs were stimulated with protein I/II for 4 hours or left untreated as controls. Total RNA was isolated, reverse-transcribed into 32P-labeled cDNA, and hybridized to Atlas human cancer cDNA expression arrays. The values are expression ratios (protein I/II / control).
RA patient | ||||
|---|---|---|---|---|
Protein product of gene | GenBank accession no. | 1 | 2 | 3 |
Insulin-like growth factor binding protein-4 | M62403 | 0.1 | 0.2 | 0.2 |
Insulin-like growth factor binding protein-5 | M65062 | - | 0.2 | - |
Cyclin-dependent kinase 4 inhibitor D | U40343 | - | - | 0.3 |
Ubiquitin-conjugating enzyme E2A | M74524 | - | - | 0.3 |
Methallothionein III | D13365 | 0.3 | - | - |