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Table 1 Evolutionary relationship between exosome components

From: The human exosome: an autoantigenic complex of exoribonucleases in myositis and scleroderma

Yeast

Escherichia coli

Human

Comments

Rrp4p

S1 RNA-binding domain

hRrp4p

Interaction with PM/Scl autoantigens; hRrp4p is a functional homologue of the yeast component

Rrp40p

S1 RNA-binding domain

hRrp40p

Interaction with PM/Scl autoantigens

Rrp41p/Ski6p

RNase PH

hRrp41p

Interaction with PM/Scl autoantigens; hRrp41p is a functional homologue of the yeast component

Rrp42p

RNase PH

hRrp42p

Partial human cDNA clone (D29958)

Rrp43p

RNase PH

No clear homologue

 

Rrp44p/Dis3p

RNase R

hRrp44p/hDis3p

hRrp44p is a functional homologue of the yeast component

Rrp45p

RNase PH

PM/Scl-75

Interaction with hRrp4p

  

OIP2p

Partial human cDNA clone

Rrp46p

RNase PH

hRrp46p

Interaction with PM/Scl autoantigens

Rrp6p

RNase D

PM/Scl-100

Interaction with hRrp4p, only present in nucleus

Mtr3p

RNase PH

No clear homologue

 

Csl4p/Ski4p

S1 RNA-binding domain

hCsl4p

hCsl4p is a functional homologue of the yeast component

  1. Adapted from [26].