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Table 1 Evolutionary relationship between exosome components

From: The human exosome: an autoantigenic complex of exoribonucleases in myositis and scleroderma

Yeast Escherichia coli Human Comments
Rrp4p S1 RNA-binding domain hRrp4p Interaction with PM/Scl autoantigens; hRrp4p is a functional homologue of the yeast component
Rrp40p S1 RNA-binding domain hRrp40p Interaction with PM/Scl autoantigens
Rrp41p/Ski6p RNase PH hRrp41p Interaction with PM/Scl autoantigens; hRrp41p is a functional homologue of the yeast component
Rrp42p RNase PH hRrp42p Partial human cDNA clone (D29958)
Rrp43p RNase PH No clear homologue  
Rrp44p/Dis3p RNase R hRrp44p/hDis3p hRrp44p is a functional homologue of the yeast component
Rrp45p RNase PH PM/Scl-75 Interaction with hRrp4p
   OIP2p Partial human cDNA clone
Rrp46p RNase PH hRrp46p Interaction with PM/Scl autoantigens
Rrp6p RNase D PM/Scl-100 Interaction with hRrp4p, only present in nucleus
Mtr3p RNase PH No clear homologue  
Csl4p/Ski4p S1 RNA-binding domain hCsl4p hCsl4p is a functional homologue of the yeast component
  1. Adapted from [26].