From: The human exosome: an autoantigenic complex of exoribonucleases in myositis and scleroderma
Yeast | Escherichia coli | Human | Comments |
---|---|---|---|
Rrp4p | S1 RNA-binding domain | hRrp4p | Interaction with PM/Scl autoantigens; hRrp4p is a functional homologue of the yeast component |
Rrp40p | S1 RNA-binding domain | hRrp40p | Interaction with PM/Scl autoantigens |
Rrp41p/Ski6p | RNase PH | hRrp41p | Interaction with PM/Scl autoantigens; hRrp41p is a functional homologue of the yeast component |
Rrp42p | RNase PH | hRrp42p | Partial human cDNA clone (D29958) |
Rrp43p | RNase PH | No clear homologue | |
Rrp44p/Dis3p | RNase R | hRrp44p/hDis3p | hRrp44p is a functional homologue of the yeast component |
Rrp45p | RNase PH | PM/Scl-75 | Interaction with hRrp4p |
OIP2p | Partial human cDNA clone | ||
Rrp46p | RNase PH | hRrp46p | Interaction with PM/Scl autoantigens |
Rrp6p | RNase D | PM/Scl-100 | Interaction with hRrp4p, only present in nucleus |
Mtr3p | RNase PH | No clear homologue | |
Csl4p/Ski4p | S1 RNA-binding domain | hCsl4p | hCsl4p is a functional homologue of the yeast component |