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Figure 5 | Arthritis Res Ther

Figure 5

From: Early and stable upregulation of collagen type II, collagen type I and YKL40 expression levels in cartilage during early experimental osteoarthritis occurs independent of joint location and histological grading

Figure 5

No correlation of molecular changes to the histological scoring. In order to directly correlate a certain histological outcome with gene expression independent of the study group or the location, samples adjacent to sections with (a) the highest (n = 8) or (b) the lowest (n = 7) modified Mankin score (mod. MS) in the anterior cruciate ligament transection-treated group were selected and were compared with (c) seven normal control samples with the lowest mod. MS in the study. Top, representative histological sample (magnification, 40 ×); bottom, corresponding mean and standard deviation of the mod. MS and of gene expression levels (% GAPDH expression). col., collagen type. a P < 0.05 versus (c), b no significant difference versus (b), c no significant difference versus (a), d P = 0.052 versus (c), e no significant difference versus (b) and (c), f no significant difference versus (a) and (c).

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Arthritis Research & Therapy

ISSN: 1478-6362

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