The role and clinical implications of G6PI in experimental models of rheumatoid arthritis

Table 1 Clinical and pathological characteristics of different arthritis models in mice

	Arthritis model
Characteristics	Collagen-induced arthritis	K/B×N arthritis	G6PI-induced arthritis
Arthritogenic antigen	Cartilage specific (CII)	Systemic (G6PI)	Systemic (G6PI)
Susceptible strain	DBA/1	KRN TCR transgenic × NOD F1 mice	DBA/1
Arthritis induction	CII immunization and boost	Spontaneous	G6PI immunization
Pathogenic cells and effector mechanisms
T cells	?	Induction phase	Induction and effector phases
Antibodies	Necessary and sufficient	Necessary and sufficient	Necessary
FcγRI or FcγRIII necessary	+	+	+
FcγRII	+	+ or - in different studies	+
C5	+	+	+
Mast cells	Uncertain	+	Unknown
Neutrophils	+	+	Unknown
Macrophages	Uncertain	Unknown	Unknown
TNF-α	+	(±)	+
IL-1	+	+	Unknown
IL-6	+	+	Unknown
Spontaneous remission	+	-	+

CII, type II collagen; G6PI, glucose-6-phosphate isomerase; TNF, tumor necrosis factor.

ISSN: 1478-6362