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Table 2 Table showing genes which were upregulated or downregulated in osteoarthritic chondrocytes (changes in mRNA expression levels >2-fold; P < 0.01)

From: Repression of anti-proliferative factor Tob1in osteoarthritic cartilage

Downregulated genes GenBank accession no. OA:N OA N Upregulated genes GenBank accession no. OA:N OA N
CHI3L1 NM_001276 0.02 0.001 0.05 COMP NM_000095 2.07 19.93 10.68
Follistatin NM_006350 0.06 0.01 0.22 BGLAP X53698 2.18 0.13 0.07
APOD NM_001647 0.08 1.10 15.68 TIMP1 X03124 2.20 12.18 6.34
EDR2 NM_004427 0.09 0.09 0.86 ARGBP2 AF049884 2.25 0.11 0.04
MMP3 X05232 0.09 1.04 10.28 FGF18 AF075292 2.35 0.40 0.16
Tob1 NM_005749 0.14 0.12 0.96 Fibronectin M10905 2.36 19.08 9.46
SLC3A2 NM_002394 0.19 0.04 0.22 Frizzled homolog 1 NM_003505 2.37 0.05 0.03
MAPK7 NM_002749 0.22 0.01 0.05 Choriolysin h 2 AA829685 2.38 0.06 0.03
SOX9 Z46629 0.26 0.29 1.14 CRTL1 NM_001884 2.43 0.76 0.31
SERPING1 NM_000062 0.27 0.76 3.27 MKP-L NM_007026 2.57 0.32 0.11
TGFBR3 NM_003243 0.27 0.05 0.15 THBS3 NM_007112 2.59 0.11 0.04
FRZB NM_001463 0.27 0.23 1.43 ADAMTS2 NM_014244 2.68 0.06 0.02
MRS3/4 AF327402 0.28 0.12 0.43 ADAMTS1 NM_006988 2.70 0.12 0.05
UBC M26880 0.31 3.29 11.04 CHM-I NM_007015 2.88 0.36 0.09
Integrin α5 NM_002205 0.35 0.36 1.17 MMP-13 X75308 2.88 0.13 0.06
GNB2L1 NM_006098 0.38 1.15 2.39 COL6A1 X15880 2.89 9.55 2.94
NF-κB_p65 Q04206 0.40 0.04 0.10 COL11A1 J04177 3.84 0.52 0.16
Pim-1 Z58595 0.41 0.05 0.15 TNFAIP6 NM_007115 4.73 0.33 0.07
NCK1 NM_006153 0.41 0.01 0.04 Thrombospondin 2 NM_003247 5.01 0.13 0.03
GSS NM_000178 0.43 0.03 0.06 COL2A1 X16468 5.67 11.62 2.20
HLA-B M81798 0.43 1.43 3.50 SPP1 NM_000582 5.78 1.96 0.38
ICAM1 NM_000201 0.44 0.09 0.26 CKTSF1B1 NM_013372 5.89 0.06 0.01
TG-interacting factor NM_003244 0.47 0.05 0.10 COL6A3 NM_004369 8.70 3.49 0.45
Phosphomannomutase 1 U86070 0.47 0.11 0.26 COL1A2 X55525 14.25 4.21 0.33
DLX5 NM_005221 0.47 0.04 0.08 TGFBI NM_000358 14.67 2.41 0.18
Biglycan NM_001711 0.49 0.21 0.50 COL3A1 X14420 31.33 15.33 0.52
TP53 NM_000546 0.50 0.14 0.34      
  1. N, mean of mRNA expression levels in the normal cartilage samples (in arbitrary units); OA, mean of mRNA expression levels in the osteoarthritic cartilage samples (in arbitrary units); OA:N, ratio of osteoarthritic to normal.