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Figure 2 | Arthritis Res Ther

Figure 2

From: Arthritis imaging using a near-infrared fluorescence folate-targeted probe

Figure 2

In vivo near-infrared fluorescent (NIRF) imaging of inflammatory joints in the lipopolysaccharide (LPS) induction model. The NIR2-folate probe was intravenously injected 2 days after LPS intra-articular injection. (a) White-light images obtained 48 hours after intra-articular LPS injection at the right ankle joint; soft tissue swelling was noted at the affected joint. (b) NIRF images obtained 24 hours after NIR2-folate injection. Note the strong fluorescence signal in the LPS-treated ankle compared with the opposite control side (enhancement ratio = 2.31). (c) A merged NIRF signal with a white-light image showing specific increased fluorescence signal intensity at the affected joint. (d) H&E-stain section of the right ankle joint showing abundant inflammatory cell infiltration at subsynovial tissues. Original magnification, 100 ×. (e) NIRF images of a longitudinal section of the LPS-treated ankles. Pseudo-color coding was used to demonstrate the stronger fluorescence signal surrounding the ankle joint.

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