Figure 5
From: Arthritis imaging using a near-infrared fluorescence folate-targeted probe
Establishment of the KRN serum transfer model. (a) Discoloration and swelling (arrow) of the right third proximal interphalangeal joint is noted in a healthy C57BL/6 mouse 4 days after KRN serum transfer. (b) Near-infrared fluorescent imaging of the right paw showed increase fluorescence signal intensity at the inflammatory joint (enhancement ratio = 1.9). (c) Correlated H&E-stain section showed abundant inflammatory cells infiltration with pannus-like formation. Original magnification, 100 ×. (d) Immunoperoxidase staining of Mac-3. Mac-3-positive cell infiltration among polymorphonuclear cells was noted in the pannus. Original magnification, 400 ×.