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Figure 4 | Arthritis Res Ther

Figure 4

From: The role of regulatory T cells in antigen-induced arthritis: aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25+T cells

Figure 4

Modulation of antigen-induced arthritis (AIA) by transfer of regulatory T cells (Treg cells). Amelioration of clinical and histological severity of AIA by transfer of 2 × 106 CD4+CD25+ cells freshly isolated from (a) naive or (b) immunized mice at the time of AIA induction (day 0; n = 6 per group). (c) Transfer of 1 × 106 in vitro pre-activated cells at the time of AIA induction (n = 6). #P < 0.05, ##P < 0.01 for CD4+CD25+ versus CD4+CD25-; +P < 0.05, ++P < 0.01 for CD4+CD25+ versus phosphate-buffered saline. Dest, joint destruction; Inf, inflammatory changes; Score; total arthritis score

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